Studies have shown that GPX4 expression is significantly elevated in GC tissues compared to matched normal tissues, and its expression levels are negatively correlated with lymph node metastasis, tumor aggressiveness, and overall prognosis, suggesting that GPX4 not only participates in the regulation of GC biological behavior but may also serve as a potential prognostic biomarker (126, 127). Here, GPX4 is linked to neoplasm.