These findings suggest that butyrate plays a critical role in modulating type 2 innate immunity during the neonatal period, highlighting a potential early-life intervention window for asthma prevention.Ahmed Kabil BASc and colleagues provided further experimental evidence that gut dysbiosis can reconfigure the immune cell interaction network—particularly the ILC2–B1 cell–innate IgE axis—leading to sustained allergic predisposition. This evidence concerns the gene IGHE and asthma.