Several studies have demonstrated the critical role of IL1R2 signaling in the inflammatory process of cardiovascular disease, and Orrem et al. reported that IL1R2, which is mediated by miR-383-3p, inhibits the activation of the inflammatory vesicle signaling pathway, which prevents apoptosis and inflammatory injury in coronary artery endothelial cells (Orrem et al., 2018). This evidence concerns the gene IL1R2 and cardiovascular disorder.