CCDC138 and cancer: For example, alpelisib targets the PI3K pathway and has shown clinical efficacy in various cancers (Mohankumar et al., 2015; Mohankumar et al., 2014a; Mohankumar et al., 2014b); CCDC138 expression may help identify patients with UCEC likely to benefit from such targeted therapies (Chang et al., 2021).