FOXO3 and Parkinson disease: The study demonstrates that the activation of the AMPK/Nrf2 and SIRT3/FoxO3a pathways leads to reduced α-synuclein oligomerization and necroptotic cell death in the substantia nigra area of a Parkinson’s disease mouse model, ultimately contributing to neurobehavioral recovery and neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity (Leem et al., 2024).