Within the context of colorectal cancer, the hypoxic microenvironment triggers the transcriptional upregulation of lncRNA STEAP3-AS1 by HIF-1α, which stabilizes the STEAP3 protein and activates the Wnt/β-catenin signaling pathway through direct interaction with its adjacent protein-coding gene, STEAP3. Here, HIF1A is linked to colorectal cancer.