Furthermore, HDAC2 was identified as a co-binding protein of DACT3-AS1 and FOXA3, with DACT3-AS1 enhancing the metastatic function of HIF-1α in HCC cells by increasing the binding affinity between FOXA3 and HDAC2, which subsequently reduced FOXA3 expression. Here, FOXA3 is linked to hepatocellular carcinoma.