This activation of the KPNA2/AKT signaling pathway leads to continuous phosphorylation of AKT (Chen et al., 2021), which not only enhances the proliferation and invasive capabilities of liver cancer cells but also promotes their metastatic potential by inducing the upregulation of epithelial-mesenchymal transition-related markers, such as N-cadherin and Vimentin (Cao et al., 2024). Here, AKT1 is linked to liver cancer.