Hypoxic cells generally exhibit greater chemo- and radio-resistance compared to normoxic cells (Yasuda, 2008), with the activation of HIF-1α-related pathways contributing to increased resistance in tumor cells (Comerford et al., 2002; Comerford et al., 2004; Moeller and Dewhirst, 2006). The gene discussed is HIF1A; the disease is neoplasm.