Zhang et al. demonstrated that under hypoxic conditions, HIF-1α activates the expression of lncRNA NEAT1 through transcriptional regulation, while NEAT1 promotes the transcription of PKM2 by binding to FOXP3 protein, thereby enhancing the glycolytic metabolism and proliferation of HCC cells (Zhang X. et al., 2020). This evidence concerns the gene PKM and hepatocellular carcinoma.