HIF1A and neoplasm: Similarly, lncRNA MALAT1 is overexpressed in various gastrointestinal cancers and has been shown to be associated with poor prognosis, supporting its role as a reliable prognostic biomarker (Song et al., 2016).Furthermore, lncRNA LncHIFCAR (i.e., MIR31HG) is induced under hypoxic conditions and acts as a co-activator of HIF-1α to regulate key transcriptional networks, promoting tumor progression and metastasis.