A human study reveals that by examining the proportions of total macrophages (CD14+), M1 macrophages (CD14+CD80+), and M2 macrophages (CD14+CD206+), as well as the differences in surface GLP-1 receptor (GLP-1R) expression in peripheral blood between coronary heart disease patients and healthy control individuals, and found that GLP-1 promotes M2 macrophage polarization and alleviates atherosclerosis through its interaction with the GLP-1R (Yang L. et al., 2021). This evidence concerns the gene GLP1R and coronary artery disorder.