Meanwhile, upregulating expression of miR-492 and downregulating expression of resistin in HUVECs improve endothelial insulin resistance and delayed the progression of atherosclerosis by suppressing the phosphorylation of signal transducer and activator of transcription 3 (STAT3), the activity of suppressor of cytokine signaling (SOCS) and P-selectin (Cai et al., 2018; Ying et al., 2014). The gene discussed is RETN; the disease is atherosclerosis.