Additionally, studies in mice have demonstrated that α-KG activates nuclear factor erythroid 2-related factor 2 (Nrf2) by activating the ERK signaling pathway in the endothelium of the thoracic aorta to counteract oxidative stress and mitochondrial impairment, thereby providing protective effects against endothelial damage induced by hyperlipidemia. This evidence concerns the gene NFE2L2 and hyperlipidemia.