Spearman correlation analysis revealed associations between RNF41 promoter methylation level in PBMCs and cytokine profiles (Figures 4D–F): weak positive correlation with TNF-α (r = 0.1841, p = 0.0139) and TGF-β (r = 0.2585, p = 0.0005), and weak negative correlation with IL-10 (r = −0.2651, p = 0.0003), suggesting epigenetic regulation of inflammatory responses during cirrhosis progression. The gene discussed is RNF41; the disease is Cirrhosis.