RNF41 and Cirrhosis: Therefore, the study aims to (1) investigate the mRNA expression profile and promoter methylation status of RNF41 in peripheral blood mononuclear cells (PBMCs) from HBV-related cirrhotic patients, (2) elucidate the clinical-pathological correlations between RNF41 promoter hypermethylation and disease progression markers, and (3) systematically evaluate the diagnostic superiority of RNF41 methylation levels over conventional noninvasive indices—including LSM, APRI, FIB-4 score—for cirrhosis staging and therapeutic monitoring.