Figure 2B illustrates a significant downregulation of RNF41 mRNA expression was observed in HBV-CLC (median 0.302, interquartile range 0.136–0.783) compared to CHB (median 1.143, interquartile range 0.448–2.163) and HC (median 0.981, interquartile range 0.675–2.018), demonstrating transcriptional suppression during cirrhosis progression. It was found that CHB and HC groups were not significantly different. Additionally, spearman rank correlation analysis between the PMR values and mRNA expression of RNF41 was performed, revealing a negative correlation (Figure 2C). This evidence concerns the gene RNF41 and Cirrhosis.