In addition to miR-214/CADM1 and miR-182/RECK, recent studies have demonstrated that the exosomal miR-29c-3p derived from M1 macrophages inhibits the invasiveness of melanoma cells through ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) (109). This evidence concerns the gene ENPP2 and melanoma.