Researchers have developed and validated AANG—a botanical formulation comprising asiatic acid (a Smad7 activator) and naringenin (a Smad3 inhibitor) that attenuates renal fibrosis and inflammation in DKD through modulation of the TGF-β/Smad3/Smad7 signaling pathway. Here, TGFB1 is linked to renal fibrosis.