In related research, a compound mixture (MIX) comprising three bioactive flavonoids—baicalin, wogonin, and wogonoside—derived from Scutellaria baicalensis has been shown to attenuate renal fibrosis in diabetic models by inhibiting activation of the TGF-β/Smads signaling cascade. The gene discussed is TGFB1; the disease is renal fibrosis.