Though inflammation increases risk of depression (68, 69), immobilization stress significantly increases the serum levels of proinflammatory cytokines IL-1β, IL-6, IFNγ, and monocyte chemoattractant protein-1 (MCP-1), while decreasing anti-inflammatory cytokines such as IL-10 (70). The gene discussed is CCL2; the disease is major depressive disorder.