These mechanisms are implicated in the molecular pathology of various cardiovascular conditions, such as diabetic cardiomyopathy, atherosclerosis, hypertensive cardiomyopathy, and heart failure.[6, 7, 8, 9, 10] This review aims to comprehensively analyze the latest discoveries to summarise the transport mechanisms by which the subcellular Ago2 performs within mammalian cells and integrate the findings on its role in cardiovascular diseases (CVDs). The gene discussed is AGO2; the disease is heart failure.