In addition to its well-established localization within the cytoplasm and nucleus, Ago2 has been identified in the mitochondria, as supported by several studies.[50,51] The mitochondrial presence of Ago2 is finely regulated by physiological conditions and pathological stimuli, such as cell differentiation[52] and diabetic damage.[7,53] Our findings indicate that both type I and type II diabetes can significantly reduce mitochondrial Ago2 levels in cardiomyocytes. Here, AGO2 is linked to diabetes mellitus.