AGO2 and cancer: Current research suggests that mitochondrial Ago2 serves multiple roles, including the regulation of translation and transcription,[52,54,55] sncRNA biogenesis,[56] and sncRNA transport.[57] Mitochondrial Ago2-mediated translation mirrors cytoplasmic RNAi, a process that requires its association with sncRNAs, primarily MitomiRs.[50] Previous studies have shown that mitochondrial Ago2 is involved in the translational repression of cardiomyocytes and RNAi in cancer cells,[54,58] with the latter mechanism dependent on Ago2’s endonucleolytic splicing activity.