The CFTR[NM_000492.4]:c.1521_1523del (p.Phe508del) variant is an established pathogenic variant associated with classical CF (13), and the CFTR[NM_000492.4]:c.1865G>A (p.Gly622Asp) variant is associated with atypical or mild CF with variable severity (14, 15). The gene discussed is CFTR; the disease is cystic fibrosis.