Variants or dysregulation of RPL10 have been linked to neurodevelopmental disorders, such as MRXS35 (OMIM#300998) and AUTSX5 (OMIM#300847), as well as certain cancers, including T-cell acute lymphoblastic leukemia (T-ALL) (8) and multiple myeloma (9). Here, RPL10 is linked to plasma cell myeloma.