HMGB1 and steatosis: Interestingly, we found that the baseline levels of platelet-derived and profibrotic TGF-ß1 (p=0.041), anti-apoptotic, angiogenic, proinflammatory high-mobility group box protein 1 (HMGB1) (p=0.047), and inflammatory pCXCR4 (p=0.003) were significantly elevated in patients with enhanced steatosis (Figure 4D–F).