Given the high rate of comorbidity between AUD and MD, and that both conditions are themselves strongly related to neuroinflammatory processes, in this study we evaluated the ability of fenofibrate -a drug that we had already demonstrated its anti-inflammatory capacity in the brain of rats treated with ethanol (Ibáñez et al., 2023; Villavicencio-Tejo et al., 2021)- to decrease behavioral symptoms associated with ethanol-induced depression, normalizing BDNF expression and dendritic arborization in the hippocampus and PFC. This evidence concerns the gene BDNF and Menkes disease.