PPARA and major depressive disorder: PPAR-α agonists have been reported in animal models of depression induced by social isolation (B. Jiang et al., 2017), stress (B. Jiang et al., 2015; Ni et al., 2018; Scheggi et al., 2016), and LPS administration (Yang et al., 2017), however the effect of PPAR-α agonists on alcohol-induced depression had not been studied so far.