These results are in line with several studies that reported, in models of depression other than that induced by alcohol, that PPAR-α agonists were able to increase the expression of BDNF (B. Jiang et al., 2015; 2017; Ni et al., 2018; Yang et al., 2017), and that this effect would be directly related to the decrease in neuroinflammation (Yang et al., 2017). This evidence concerns the gene BDNF and major depressive disorder.