Decursin significantly reduces viral load in the lungs of influenza-infected models (>1 log), downregulates the ratio of p-PI3K/PI3K and p-Akt/Akt, and regulates the balance of IL-6, IL-17, TNF-α, and IL-10, effectively alleviating morphological abnormalities in lung tissue (Tang et al., 2025). The gene discussed is TNF; the disease is influenza.