Further in vivo experiments showed that injecting MPTP with SP (Gao et al., 2015a) or Ganoderma lucidum polysaccharides (Yang et al., 2017) significantly increased the activity of antioxidant enzymes and the content of superoxide anions, such as SOD, GSH Px, CAT, LDH in the striatum of Parkinson’s mice, while reducing the content of H2O2, MDA, etc., indicating that SP also has strong antioxidant activity in vivo. This evidence concerns the gene SOD1 and Parkinson disease.