The results of experimental studies done, point to multiple signaling pathways that result in carcinogenesis including the promotion of ROS production, inhibition of DNA repair, regulation of metallothioneins by miRNAs and transcription factors, promotion of cancer cell proliferation & invasion though p53 protein, E-cadherin, transcription factors, increased expression of proto-oncogenes as well as disruption of processes such DNA methylation by activation of the PI3K/AKT/mTOR pathway. The gene discussed is AKT1; the disease is cancer.