Among the 40 pairs of BCR V-J genes exhibiting differential abundance between malignant and benign tumors patients, 11 pairs demonstrated statistically significant differences (p < 0.01), though these exploratory findings remain uncorrected for multiple testing due to sample size limitations and require validation in larger cohorts, with IGHV3-25_IGHJ5 and IGHV3-25_IGHJ2 being the V-J pairs more abundant in malignant tumors patients. Here, BCR is linked to benign neoplasm.