The role of CHAC1 in ccRCC exhibits significant complexity, with its expression levels and functional effects highly dependent on the tumor stage and aggressiveness, manifesting a “stage-dependent” dual role: CHAC1 Low Expression as a Potential Marker of Poor Prognosis (Tumor Suppressor Context): Li et al. This evidence concerns the gene CHAC1 and nonpapillary renal cell carcinoma.