To investigate an in vivo biopsy method based on CT-MRI fusion image registration and evaluate its value for improving the accuracy of preoperative core needle biopsies(CNBs) histological grading in soft tissue sarcoma (STS)and determining the correlation between multiparametric MRI(mp MRI) and both STS French Federation of Cancer Center (FNCLCC) grading and the Ki-67 labeling index (LI). This evidence concerns the gene MKI67 and telomere syndrome.