HIF-1α is pivotal in tumor progression, previous studies have shown that the expression of HIF-1α in lung cancer tissues is significantly higher than that in normal lung tissues, and its high expression promotes a series of reactions such as tumor proliferation, migration, and invasion, and this process is associated with the PI3K/AKT/mTOR signaling pathway (20, 21). The gene discussed is HIF1A; the disease is lung cancer.