RNF43 and neoplasm: The volcano map of mutation difference analysis showed that ARID1A, CIC, and other genes were significantly enriched in the G2 group (Supplementary Figure 5C), and the pathway enrichment results suggested that the microRNAs pathway, DNA damage repair, and tumor suppressive gene mutations were significantly enriched in G2 group: RNF43 codon 659-mutated and Non-class 1 BRAF-mutated.