RNF43 and colorectal carcinoma: Different from the previous analysis process, we also included RNF43 wild-type in this part, and a total of 3937 CRC patients with survival data were recorded and screened, which were divided into three groups: G1: RNF43 codon 659-mutated, Non-class 1 BRAF-mutated, and MSl-H, G3: RNF43 Non-codon 659-mutated (including RNF43 wild-type), Class 1 BRAF-mutated, and Non-MSl-H; G2: Non-G1 and Non-G3.