TP53 and cancer: GSEA analysis revealed significant activation of genes in key pathways, such as Pathways in Cancer (NES = 1.559, P.adjust = 0.015), Cell Cycle (NES = 2.374, P.adjust < 0.001), DNA Replication (NES = 1.904, P.adjust < 0.001), p53 Signaling (NES = 1.616, P.adjust = 0.021), and Homologous Recombination (NES = 1.746, P.adjust = 0.001) (Figure 4C).