In endometrial carcinoma cells, suppression of KLF9 significantly upregulates aldehyde-metabolizing enzyme genes ALDH1A1 and AKR7A2, while concurrently inhibiting detoxification genes SULT1A1 and xenobiotic efflux transporter ABCC4, directly disrupting metabolic homeostasis and cell detoxification, which is confirmed in endometrial cancer samples (25). The gene discussed is KLF9; the disease is endometrial cancer.