KLF9 and neoplasm: The microenvironment reshapes its molecular niche and pushes it towards opposite functional poles, serving as both a survival support factor for primary tumors and a stemness inhibitor in metastatic lesions.These findings collectively suggest that KLF9 acts as a tumor suppressor in metastatic niches by countering stemness but may paradoxically support tumor cell survival in primary sites, highlighting its potential as a therapeutic target and prognostic marker in OC (45, 46).