KRAS and pachyonychia congenita: According to the International Cancer Genome Consortium (ICGC) data portal project, substitutions in Kirsten rat sarcoma virus gene (KRAS) occur in 78% of PC, and of them 70% are single-base missense substitutions on codon 12, with G12D (40%), G12V (31%), and G12R (19%) being the three most common mutations (2).