KRAS and pachyonychia congenita: In view of the considerable number of mechanisms involved in the development and progression of PC that are primarily driven by KRAS, we aimed to examine the transcriptomic distinctions between KRAS-mutated and KRAS-WT PCs using both a comprehensive transcriptomic approach on public datasets and quantitative real-time reverse transcription PCR (RT-qPCR) analysis on an independent cohort of primary PC.