Eleven risk factors related to IgAN with AKI were identified, including nephrotic syndrome (NS), T score from the Oxford histological classification, estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), 24-hour urinary protein quantification (24h-UPRO), C-reactive protein (CRP), systemic inflammatory response index (SIRI), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-CRP ratio (LCR), and prognostic nutritional index (PNI). The gene discussed is CRP; the disease is acute kidney injury.