Chen et al. (2022) reported that SOCS2 expression promoted ferroptosis by facilitating the ubiquitination degradation of SLC7A11, which may increase the efficiency of HCC radiotherapy and improve patient prognosis. Triggering ferroptosis suppresses the proliferation of HCC cells, thereby reversing tumorigenesis, improving the efficacy of immunotherapy, and enhancing the anti-tumor immune response (Liu et al., 2024b). This evidence concerns the gene SOCS2 and hepatocellular carcinoma.