In addition, Zhou et al. (2024) identified a distinct subset of THBS2-expressing CAFs as key drivers of oxaliplatin resistance, wherein COL8A1 secreted from these cells activates the PI3K-AKT signalling pathway, thereby inducing epithelial-mesenchymal transition and promoting chemoresistance in CRC. The gene discussed is COL8A1; the disease is colorectal carcinoma.