The results of the meta-analysis showed that exercise can improve malondialdehyde (MDA), standardized mean difference (SMD) = −1.29, 95% CI [−1.87 to −0.71], P < 0.0001 in patients with T2DM; and improve superoxide dismutase (SOD), SMD = 0.59, 95% CI [0.17–1.01], P = 0.006 in patients with T2DM. Here, SOD1 is linked to type 2 diabetes mellitus.