CRP and obesity due to melanocortin 4 receptor deficiency: Patients aged 56 years or older (Fig. 5A; p = 0.0086), those with low hemoglobin (Fig. 5B; p = 0.0052), obesity (Fig. 5C; p < 0.0001), or elevated CRP levels (Fig. 5D; p < 0.0001) had significantly reduced survival and a higher likelihood of requiring ventilation.