PSMD1 and obesity due to melanocortin 4 receptor deficiency: For illustrative purposes, a patient presenting with obesity (assigned a score of 1; ∼80 points), elevated ferritin levels (e.g., 2,800 ng/mL; ∼30 points), a high neutrophil-to-lymphocyte ratio (e.g., 30; ∼60 points), and increased anti-S1 IgG titers (e.g., 2.5; ∼10 points) would yield a cumulative nomogram score of approximately 180 points.