CRP and obesity due to melanocortin 4 receptor deficiency: Kaplan–Meier curves reveal that advanced age (≥ 56 years), low hemoglobin levels (<14.1 g/dL), obesity, elevated CRP (≥ 67 mg/mL), low lymphocyte count (<9.3), high ferritin (≥877 μg/L), high absolute neutrophil counts (≥ 8.9), and elevated D-dimer levels (≥ 0.75 μg/mL) significantly impact survival and mechanical ventilation requirements in hospitalized COVID-19 patients (Fig. 5).