Integrated analysis of transcriptomics and metabolomics data reveals that SRL alleviates pulmonary fibrosis through modulation of AMPK and PPAR signaling pathways mediated by genes such as SCD, HMGCS2, LTA4, and FADS2. These genes play crucial roles in regulating cellular energy metabolism and are closely linked to amino acid and fatty acid metabolic pathways. This evidence concerns the gene HMGCS2 and pulmonary fibrosis.