HLA-DRB1 and cancer: Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses (Figure S3G,H, and Table S13) revealed that the top upregulated genes (start vs. end) in cancer‐pre cells (Curve1 and Curve2) were enriched in antigen processing and presentation pathways, such as CD74 [32], HLA‐DRB1 [33], HLA‐DRA [34], PSME1/2 [35], and CTSB [36].