The specific goal of this study was to investigate differential expressions of receptors of advanced glycation end product (RAGE), its ligands high mobility group box protein (HMGB1) and calcium binding protein (S100A10), as well as the inflammatory mediators nuclear factor kappa B p65 subunit (NFκB), cyclooxygenase 2 (COX-2), and interleukin 8 (IL-8), at the placental tissue level in pregnancies associated with PE in comparison to normal pregnancies and those associated with a well-known inflammatory condition, chorioamnionitis. Here, PTGS2 is linked to chorioamnionitis.