Variants in FIG4 can cause four different diseases: bilateral temporo-occipital polymicrogyria (OMIM 612691), amyotrophic lateral sclerosis 11 (OMIM 612577), Charcot–Marie–Tooth disease, type 4J (CMT4J) (OMIM 611228), and Yunis–Varón syndrome (YVS) (OMIM 216340). The gene discussed is FIG4; the disease is Yunis-Varon syndrome.