To investigate further the precise role of STK11, signaling cascades, and molecular pathways underlying PJS in this family, we performed transcriptomic analysis using RNA-seq of primary dermal fibroblasts derived from PJS1-2 (Figures 2a, 2b, 2c, and 2d; Figures S1 and S2, and Table S2). This evidence concerns the gene STK11 and Peutz-Jeghers syndrome.