Moreover, knockdown of METTL3, METTL14, or WTAP led to increased nuclear localization of MALAT1 in HBV/HBx-expressing HCC cells, indicating a link between the nucleocytoplasmic shuttling of MALAT1 and its m6A modification (Fig. 5C). The gene discussed is MALAT1; the disease is hepatocellular carcinoma.