FZD1 and colorectal cancer: In addition to its role in breast cancer, the overexpression of FZD1 attenuated the increase in cell apoptosis and decrease in cell proliferation in imatinib-resistant renal cell carcinoma cells 35 and the drug that inhibits the Wnt signaling pathway suppresses the expression of FZD1 and promotes the cell death in colorectal cancer 36.