In addition to its role in breast cancer, the overexpression of FZD1 attenuated the increase in cell apoptosis and decrease in cell proliferation in imatinib-resistant renal cell carcinoma cells 35 and the drug that inhibits the Wnt signaling pathway suppresses the expression of FZD1 and promotes the cell death in colorectal cancer 36. This evidence concerns the gene FZD1 and hereditary clear cell renal cell carcinoma.