Finally, Poria cocos-derived poricoic acid A upregulates SIRT3 and promotes β-catenin K49 deacetylation, effectively attenuating renal fibroblast activation and renal interstitial fibrosis in vivo and in vitro296, suggesting poricoic acid A may serve as a promising therapeutic candidate in fibrosis-related renal diseases. The gene discussed is SIRT3; the disease is kidney disorder.