TGFB1 and keloid: Additionally, activation of homeodomain-interacting protein kinase (HIPK2) has been shown to promote fibrosis in multiple organs through signaling pathways such as Wnt/β-catenin, TGF-β, and Notch Moreover, the overexpression of m6A writer ZC3H13 mediated the m6A modification of HIPK2 to maintain its stability, then promoted the proliferation and migration of human keloid fibroblasts (HKFs) but inhibited apoptosis in vitro, which led to keloid formation 125.