This revealed that orally administered sesamin reduced the mRNA levels of Th2 cytokines including il4, il5, il13, and il31 relative to those in the AD group (Fig. 8A), reduced those of Th1 cytokines (ifng and tnfa) and Th17 cytokines (il17) (Fig. 8B, 8C), but did not alter those of il6 and the keratinocyte chemokine tslp (Supplementary Fig. 5A, 5B). This evidence concerns the gene TNF and Alzheimer disease.