TWIST1 and ovarian carcinoma: TWIST is a transcription factor involved in drug resistance of ovarian cancer and the combination of PAMAM dendrimers along with mesoporous silica nanoparticles were used to carry the siRNA targeting TWIST gene for down-regulation of TWIST mRNA to overcome cisplatin-resistant ovarian cancer cells by increasing the sensitivity of cancer cells for chemotherapeutics to cause tumor regression 127, 128.