A heatmap analysis was conducted using a TCGA dataset of LUAD patients for TNFAIP6, PLK1, and mesenchymal markers including CDH2, SNAI1, and SNAI2 in paired normal tissue (Fig. 1D-E, left, normal) and adjacent tumor tissues (Fig. 1D-E, right, LUAD) depending on stages. This evidence concerns the gene SNAI2 and neoplasm.