We integrated TCGA and GEO datasets: (1) TCGA-LUAD: identified lncRNAs significantly upregulated in lung adenocarcinoma (LogFC > 4, p < 0.01); (2) GSE144520: Compared with sensitive A549 lung cancer cells, lncRNAs upregulated in cisplatin-resistant A549 cells (LogFC > 4, p < 0.01); (3) GSE18842: Transcriptome sequencing dataset of lung cancer tissues and normal tissues, screening and identifying lncRNAs upregulated in cisplatin-resistant lung cancer cells, intersecting to obtain three long non-coding RNAs: LINC02802, NKILA, and SENCR (Figure 1A). The gene discussed is SENCR; the disease is lung cancer.