In type 1 diabetic (T1DM) mice, dihydromyricetin (DHM), a flavonoid, inhibits NF-κB activation by binding to sphingosine kinase-1 (SphK1) and reducing its activity and protein expression, ultimately mitigating HG-induced expression of fibrosis and inflammatory molecules in GMCs 161. The gene discussed is SPHK1; the disease is type 1 diabetes mellitus.