CD8A and neoplasm: This vascular dysfunction elevates interstitial fluid pressure, exacerbates hypoxia, and fosters an immunosuppressive TME marked by diminished CD8+ T-cell infiltration and enrichment of myeloid-derived suppressor cells (MDSCs), M2-polarized tumor-associated macrophages (TAMs), and regulatory T cells (Tregs)1, 3, 4.