Moreover, in CisS tumor spheroids, cisplatin treatment substantially decreased the expression of CREB mRNA and protein (Fig. 4A and 4B), and decreased the levels of TNKS and KDM6A proteins (Fig. 6A and 6B), resulting in a substantial increase in apoptotic cell death (Fig. 1D and 1E). This evidence concerns the gene CREB1 and neoplasm.