NLRP3 and persistent truncus arteriosus: To verify the effects of S100A8/A9 on cardiac inflammation through NF-κB signaling, we examined the infiltration of proinflammatory cells, the mRNA levels of proinflammatory cytokines and the protein levels of NF-κB and NLRP3 in WT and S100A9-KO mice 4 weeks after TAC.