CDK9 and neoplasm: Given that the cooperative mechanism between CREPT and CDK9, and the differential expression pattern observed in LUAD patients where CREPT is abundantly expressed in tumor cells while CDK9 expression remains relatively unchanged between tumor and adjacent non-tumor tissues (Figure S5F-S5I), we hypothesized that targeting CREPT might provide a more tumor-specific approach to inhibiting CDK9-mediated tumor growth.